Prof. Huang Chengdong
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Author:臧晶晶  Release time:2020-06-01   Access times:173


Name: 

HUANG Chengdong Professor

Address:

Room 705, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230026, PR China

Tel:

0551-63600743

E-mail:

huangcd@ustc.edu.cn

 

EDUCATION AND RESEARCH EXPERIENCE

1997-2001

Dalian University of Technology
Bachelor
Industrial Catalysis

2001-2004


2004-2010


2010-2012

Dalian Institute of Chemical Physics, Chinese Academy of Sciences
Master
Biochemical Engineering

Auburn University

Ph.D., Biochemistry

Stony Brook University

Department of Biochemistry and Cell Biology, Postdoctoral Fellow

2012-2015



2015-2017



2017


Rutgers University

Department of Chemistry and Chemical Biology, Postdoctoral Fellow

University of Minnesota,

Department of Biochemistry, Molecular Biology, and Biophysics, Postdoctoral Fellow

St. Jude Children’s Research Hospital, Department of Structural Biology, Associate Scientist


2017-present

University of Science and Technology of China

School of Life Sciences, Professor

 

RESEARCH INTERESTS

Our current work primarily focuses on determination of the structural and dynamic basis for the function and assembly of large protein machineries.

 

CURRENT RESEARCH PROJECTS

1.

Mechanistic studies of the interaction of the large dynamic molecular chaperone Hsp90 with its clients. General Program

2.

Mechanistic study of clients transportation by the protein machine p97 using solution NMR. General Program

 

REPRESENTATIVE PUBLICATIONS

  1. Huang, Chengdong; Kalodimos, Charalampos, G. Structures of Large Protein Complexes by NMR. Annu. Rev. Biophys. 46, 317-336(2017).

  2. Huang, Chengdong; Rossi, Paolo; Saio, Tomohide; Kalodimos, Charalampos, G. Structural basis for the antifolding activity of a molecular chaperoneNature. 537, 202-206 (2016).

  3. Rath, Poonam; Huang, Chengdong; Wang, Tao; Wang, Tianzhi; Li, Huilin; Prados-Rosales, Rafael; Elemento, Olivier; Casadevall, Arturo; Nathan, Carl F. Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci.USA. 110(49), E4790-4797 (2013).

  4. Huang, Chengdong*; Li, Guangtao*; Lennarz, William J. Dynamic flexibility of the ATPase p97 is important for its interprotomer motion transmission. (*Equal contribution) Proc. Natl. Acad. Sci. USA. 109(25), 9792-9297 (2012).

  5. Li, Guangtao*; Huang, Chengdong*, Zhao, Gang; Lennarz, William J. Interprotomer motion-transmission mechanism for the hexameric AAA ATPase p97. (*Equal contribution) Proc. Natl. Acad. Sci. USA, 109(10), 3737-3741 (2012).

  6. Huang, Chengdong; Bhaskaran, Rajagopalan; Mohanty, Smita. Eukaryotic N-glycosylation Occurs Via membrane-anchored C-terminal domain of Stt3p subunit of oligosaccharyl transferase. J. Biol. Chem. 287(39), 32450-32458 (2012).

  7. Huang, Chengdong; Mohanty, Smita. Challenging the Limit: NMR Assignment of a 31 kDa Monomeric Helical Membrane Protein. J. Am. Chem. Soc. 132, 3662–3663 (2010).