EDUCATION AND RESEARCH EXPERIENCE 2004-2008 | University of Science and Technology of China
Bachelor，Biology | 2008-2013 | University of Science and Technology of China
Doctor，Biology | 2014-2014
2014-2019 | Max Planck Institute for Biophysical Chemistry Department of NMR-based Structural Biology，Postdoc Leibniz-Institute for Molecular Pharmacology Department of Biophysics, Postdoc | 2019-present | University of Science and Technology of China, Hefei National Laboratory for Physical Sciences at the Microscale, Research fellow |
RESEARCH INTERESTS My research interest focuses on membrane protein structure, dynamic and function studies, including ion channels, receptors and intramembrane protease. Technically, I am also interested in developing biological solid-state NMR methods, including isotope labeling strategy, recoupling pulse sequences and 1H detection methods at ultra-high MAS spinning rate. |
REPRESENTATIVE PUBLICATIONS (1) Zhang Jin; Li Juan; Wang Yusong; Shi Chaowei*; NMR methods to detect fluoride binding and transport by membrane proteins, Methods in Enzymology, 2024,696:25-42 (2) Ling Shenglong; Meng Xianyu; Zhang Yuan; Xia Zhemin; Zhou Yingxin; Yang Fan; Shi Pan*; Shi Chaowei*; Tian Changlin*; Structural insights into asymmetric activation of the calcium-sensing receptor–Gq complex, Cell Research, 2024, 34(2): 169-172 (3) Li Hao; Zhang Jin; Wang Zilong; Shi Pan; Shi Chaowei*; Genetically encoded site-specific 19F unnatural amino acid incorporation in V. natriegens for in-cell NMR analysis, Protein expression and purification, 2024, 219:106461 (4) Zhang Jin; Song Dan; Florian Karl Schackert; Li Juan; Xiang Shengqi; Tian Changlin; Gong Weimin; Paolo Carloni; Mercedes Alfonso-Prieto; Shi Chaowei*; Fluoride permeation mechanism of the Fluc channel in liposomes revealed by solid-state NMR, Science Advances, 2023, 9(34): eadg9709 (5) Zhao Rui; Shi Pan; Cui Ji-bin; Shi Chaowei*; Wei Xiao-Xiong; Luo Jie; Xia Zhemin; Shi WeiWei; Zhou Yingxin; Tang Jiahui; Tian Changlin; Meininghaus Mark; Bierer Donald; Shi Jing*; Li Yiming*; Liu Lei* ; Single‐Shot Solid‐Phase Synthesis of Full‐Length H2 Relaxin Disulfide Surrogates, Angewandte Chemie International Edition, 2023, 62(6): e202216365 (6) Song Dan; Kuang Lisha; Yang Lin; Wang Lei; Li Hao; Li Xiu; Zhu Zhimin; Shi Chaowei*; Zhu Haining*; Gong Weimin*; Yin and yang regulation of stress granules by Caprin-1, Proceedings of the National Academy of Sciences, 2022, 119(44): e2207975119 (7) Li Longmei; Zhang Jin; Sun Wenjing; Gong Weimin; Tian Changlin; Shi Pan*; Shi Chaowei*; Allosteric conformational changes of G proteins upon its interaction with membrane and GPCR, Chinese Chemical Letters, 2022, 33(2): 747-750 (8) Shi Wei-Wei#; Shi Chaowei#; Wang Tong-Yue; Li Yu-Lei; Zhou Yong-Kang; Zhang Xu-Han; Bierer Donald; Zheng Ji-Shen; Liu Lei ; Total Chemical Synthesis of Correctly Folded Disulfide-Rich Proteins Using a Removable O-Linked β- N-Acetylglucosamine Strategy, Journal of the American Chemical Society, 2022, 144(1): 349-357 (9) Wang Yongjin#; Zhou Yang#; Shi Chaowei#; Liu Jiacong; Lv Guohua; Huang Huisi; Li Shengrong; Duan Liping; Zheng Xinyi; Liu Yue; Zhou Haibo; Wang Yonghua; Li Zhengqiu; Ding Ke; Sun Pinghua; HuangYun; Lu Xiaoyun; Zhang Zhi-Min; A toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria, Nature Communications, 2022, 13(1): 6434 (10) Shi Chaowei*; Oester Carl; Bohg Claudia; Li Longmei; Lange Sascha; Chevelkov Veniamin; Lange Adam*; Structure and Dynamics of the Rhomboid Protease GlpG in Liposomes Studied by SolidState NMR, Journal of the American Chemical Society, 2019, 141(43): 17314-17321
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