Prof. Shi Chaowei
Author:臧晶晶  Release time:2020-06-01   Access times:800


Chaowei Shi


Hefei National Laboratory for Physical Sciences at the Microscale , University of Science and Technology of China, Hefei, Anhui, 230026, PR China








University of Science and Technology of China


University of Science and Technology of China



Max Planck Institute for Biophysical Chemistry

Department of NMR-based Structural BiologyPostdoc

Leibniz-Institute for Molecular Pharmacology

Department of Biophysics, Postdoc


University of Science and Technology of China, Hefei National Laboratory for Physical Sciences at the Microscale, Research fellow



My research interest focuses on membrane protein structure, dynamic and function studies, including ion channels, receptors and intramembrane protease. Technically, I am also interested in developing biological solid-state NMR methods, including isotope labeling strategy, recoupling pulse sequences and 1H detection methods at ultra-high MAS spinning rate.



  1. Chaowei Shi, Carl Öster, Claudia Bohg, Longmei Li, Sascha Lange, Veniamin Chevelkov, Adam Lange, Structure and Dynamics of the Rhomboid Protease GlpG in Liposomes Studied by Solid-State NMR. J Am Chem Soc 2019 141, 17314-17321

  2. Chaowei Shi, Yao He, Kitty Hendriks, Bert L. de Groot, Xiaoying Cai, Changlin Tian, Adam Lange, Han Sun, A single NaK channel conformation is not enough for non-selective ion conduction. Nature Communications 9, 717 (2018).

  3. Chaowei Shi, Pascal Fricke, Lin Lin, Veniamin Chevelkov, Melanie Wegstroth, Karin Giller, Stefen Becker, Martin Thanbichler, Adam Lange, Atomic-resolution structure of cytoskeletal bactofilin by solid-state NMR. Science advances 1, e1501087 (2015).

  4. Suresh Vasa, Lin Lin, Chaowei Shi, Birgit Habenstein, Dietmar Riedel, Juliane Kuhn, Martin Thanbichler, Adam Lange, beta-Helical architecture of cytoskeletal bactofilin filaments revealed by solid-state NMR. Proceedings of the National Academy of Sciences 112, E127-136 (2015).

  5. Juan Li, Chaowei Shi, Demeng Sun, Yao He, Chaohua Lai, Pei Lv, Ying Xiong, Longhua Zhang, Fangming Wu, Changlin Tian, The HAB1 PP2C is inhibited by ABA-dependent PYL10 interaction. Scientific reports 5, 10890 (2015).

  6. Chaowei Shi, Hannes K. Fasshuber, Veniamin Chevelkov, Shengqi Xiang, Birgit Habenstein, Suresh K. Vasa, Stefen Becker, Adam Lange, BSH-CP based 3D solid-state NMR experiments for protein resonance assignment. Journal of biomolecular NMR 59, 15-22 (2014).

  7. Juan Li, Chaowei Shi, Yuan Gao, Kaiqi Wu, Pan Shi, Chaohua Lai, Liu Chen, Fangming Wu, Changlin Tian, Structural studies of Mycobacterium tuberculosis Rv0899 reveal a monomeric membrane-anchoring protein with two separate domains. Journal of molecular biology 415, 382-392 (2012).

  8. Chaowei Shi, Fang Han, Ying Xiong, Changlin Tian, A gas chromatography-mass spectrometry method to monitor detergents removal from a membrane protein sample. Protein expression and purification 68, 221-225 (2009).

  9. Jinxiu Zhang, Xiaojie Yan, Chaowei Shi, Xue Yang, Yu Guo, Changlin Tian, Jiafu Long, Yuequan Shen, Structural basis of beta-catenin recognition by Tax-interacting protein-1. Journal of molecular biology 384, 255-263 (2008).

  10. Chaowei Shi, Wei Shao, Ying Xiong, Changlin Tian, A gas chromatographic method for quantification of detergents frequently used in membrane protein structural studies. Analytical biochemistry 383, 326-328 (2008).